TABLE 1.
Effect of treatments on development of dental caries in rats (Keyes' score)a
| Treatment | Smooth-surface caries | Smooth-surface severity |
Sulcal-surface caries | Sulcal-surface severity (mean [SD]) |
|||
|---|---|---|---|---|---|---|---|
| Dsb | Dmc | Ds | Dm | Dxd | |||
| Negative control (deionized water) | 24.0 (7.9)A | 13.2 (6.6)A | 2.4 (1.8)A | 43.2 (4.6)A | 38.6 (2.8)A | 21.6 (4.4)A | 8.0 (5.1)A |
| Vehicle control (1% DMSO) | 22.8 (6.3)A | 16.0 (8.8)A | 0.8 (1.3)A | 42.6 (7.6)A | 41.8 (1.1)A | 19.2 (5.8)A | 5.0 (5.7)A |
| Fluoride (250 ppm) | 11.0 (4.1)B | 2.4 (2.6)B | NDe | 27.4 (5.7)B | 23.0 (4.2)B | 7.4 (3.5)BC | ND |
| Compound (5 μg/ml) | 14.2 (5.1)AB | 2.8 (1.3)B | ND | 39.2 (3.8)AC | 34.8 (6.2)A | 14.2 (4.1)AC | 0.8 (0.8)B |
| Compound (10 μg/ml) | 10.0 (3.9)B | 2.4 (2.1)B | ND | 30.8 (4.3)BC | 22.2 (3.4)B | 2.8 (2.7)B | ND |
a
Table values denote means with SD in parentheses (n = 5). Values followed by the same letter are not significantly different from each other (P > 0.05) (ANOVA; comparison for all pairs using the Tukey-Kramer HSD).
b
Ds, dentin exposed.
c
Dm, 3/4 of the dentin affected.
d
Dx, whole dentin affected.
e
ND, not detectable.