TABLE 2.
MICs of meropenem (MEM) and ceftazidime (CFZ), with and without d- and l-captopril (d- and l-CAP), versus various Gram-negative bacteria
| Strain (inhibitor) | Genotype | MIC |
|||||
|---|---|---|---|---|---|---|---|
| MEM | MEM + d-CAP (8 mg/liter) | MEM + l-CAP (8 mg/liter) | CFZ | CFZ + d-CAP (8 mg/liter) | CFZ + l-CAP (8 mg/liter) | ||
| E. coli 25922 | <0.125 | <0.125 | <0.125 | 0.125 | <0.125 | <0.125 | |
| E. coli J53 + NDM-1 clone | blaNDM-1 | 64 | 8 | 8 | 512 | 8 | 32 |
| E. coli J53 + NDM-1 transconjugant | blaNDM-1 | 128 | 16 | 16 | 512 | 16 | 32 |
| E. coli J53 + VIM-2 clone | blaVIM-2 | 8 | 2 | 4 | 32 | 8 | 16 |
| E. coli J53 + VIM-2 transconjugant | blaVIM-2 | 2 | 1 | 1 | 32 | 4 | 8 |
| E. coli J53 + IMP-1 clone | blaIMP-1 | 1 | 0.25 | 0.5 | 128 | 32 | 32 |
| K. pneumoniae IR16 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaSHV-1 blaNDM-1 | 128 | 8 | 128 | |||
| E. coli IR10 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaOXA-1 blaNDM-1 | 64 | 2 | 64 | |||
| K. pneumoniae IR8 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaSHV-1 blaNDM-1 | 16 | 2 | 16 | |||
| E. coli IR15 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaOXA-1 blaNDM-1 | 8 | 0.25 | 8 | |||
| K. pneumoniae IR19 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaSHV-1 blaNDM-1 | 8 | 1 | 8 | |||
| E. coli IR24 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaOXA-1 blaNDM-1 | 512 | 32 | 512 | |||
| E. coli IR60 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaOXA-1 blaNDM-1 | 128 | 32 | 128 | |||
| K. pneumoniae HR8 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaOXA-1 blaSHV-1 blaNDM-1 | 64 | 4 | 64 | |||
| K. pneumoniae N16 (NDM-1) | blaDHA-1 blaCTX-15 blaTEM-1 blaSHV-1 blaNDM-1 | 32 | 4 | 16 | |||
| K. pneumoniae A33 (VIM-4) | blaCTX-15 blaTEM-1 blaSHV-12a blaVIM-4 | 8 | 1 | 16 | |||
| K. pneumoniae A34 (VIM-4) | blaCTX-15 blaTEM-1 blaSHV-12a blaVIM-4 | 8 | 1 | 8 | |||
| K. pneumoniae A35 (VIM-4) | blaCTX-15 blaTEM-1 blaSHV-12a blaVIM-4 | 16 | 4 | 16 | |||
| K. pneumoniae B12 (IMP-4) | blaCTX-15 blaTEM-1 blaSHV-12a blaIMP-4 blaOXA-1 | 8 | 1 | 4 | |||
| S. marcescens B13 (IMP-4) | blaDHA-1 blaAMPC blaTEM-1 blaIMP-4 | 4 | 1 | 4 | |||
| K. pneumoniae B19 (IMP-4) | blaCTX-15 blaTEM-1 blaSHV-12a blaIMP-4 | 32 | 2 | 16 | |||
| P. aeruginosa 4470 (VIM-2) | blaAMPC blaVIM-2 | 512 | 512 | 512 | |||
| P. aeruginosa (AIM-1) | blaAMPC blaAIM-1 | 512 | 512 | 512 | |||