TABLE 2.
Population pharmacokinetic parameter estimates obtained after fitting the final model to the original data set and to 1,000 bootstrap samplesa
| Parameter | Model result |
Bootstrap result |
|||
|---|---|---|---|---|---|
| Population estimate (SEE)b | % RSEc | Mean | Median | 95% confidence interval | |
| Volume of distribution (liters) | 63.70 (3.2) | 5.0 | 63.44 | 63.3 | 57.50–69.90 |
| Clearance (liters/h) | 6.62 (0.26) | 3.8 | 6.70 | 6.64 | 5.980–7.770 |
| Absorption rate constant (1/h) | 0.712 (0.03) | 4.3 | 0.73 | 0.721 | 0.551–0.940 |
| Pregnancy on CL | 1.17 (0.03) | 2.6 | 1.19 | 1.18 | 1.030–1.390 |
| Postpartum on CL | 0.736 (0.02) | 2.7 | 0.74 | 0.735 | 0.646–0.837 |
| IC50 (μg/ml) | 0.239 (0.01) | 4.3 | 0.24 | 0.235 | 0.131–0.373 |
| Tablet on bioavailability | 1.200 (0.05) | 4.0 | 1.19 | 1.190 | 1.110–1.290 |
| Interindividual variance of volume of distribution | 0.183 (0.03) | 16.0 | 0.19 | 0.189 | 0.112–0.280 |
| Interindividual variance of clearance | 0.130 (0.01) | 6.6 | 0.13 | 0.131 | 0.101–0.166 |
a
Based on 964/1,000 successful runs.
b
SEE, standard error of the estimate.
c
RSE, relative standard error.