TABLE 1.
Clinical isolates used in the study
| Clinical strain |
Species | Parent strain | Resistance mechanism/genotypea | Reference or source | |
|---|---|---|---|---|---|
| DSY no. | Alternative no. | ||||
| DSY281 | C23 | C. albicans | Related to DSY284 | WT | 32 |
| DSY284 | C39 | C. albicans | ERG11 (S405F), TAC1 (G980E)b | 32 | |
| DSY347 | C33 | C. albicans | Related to DSY348 and DSY289 | WT | 25 |
| DSY288 | C34 | C. albicans | ERG11 (S405F) | 25 | |
| DSY289 | C26 | C. albicans | ERG11 (S405F, Y132H), TAC1 (A736V) | 25, 29 | |
| DSY348 | C82 | C. albicans | ERG11 (S405F), TAC1 (A736V) | 25, 29 | |
| DSY290 | C27 | C. albicans | Related to DSY291, DSY292 | WT | 25 |
| DSY291 | C37 | C. albicans | ERG11 (G464S) (R467K) | 15, 25 | |
| DSY292 | C40 | C. albicans | ERG11 (G464S) (R467K, Y132H),b MRR1 (P683H)b | 15, 25 | |
| DSY294 | C43 | C. albicans | Related to DSY296 | WT | 14 |
| DSY296 | C56 | C. albicans | ERG11 (G464S), TAC1 (N977D) | 14 | |
| DSY2321 | C. albicans | Related to DSY2322 and DSY2323 | ERG11 (S405F)b | 29 | |
| DSY2322 | C. albicans | ERG11 (S405F), TAC1 (G980E) | 29 | ||
| DSY2323 | C. albicans | ERG11 (S405F), TAC1 (G980E) | 29 | ||
| DSY731 | C. albicans | Related to DSY732 and DSY735 | WT | 29 | |
| DSY732 | C. albicans | TAC1 (ΔM677)c | 29 | ||
| DSY735 | C. albicans | TAC1 (ΔM677), i (5L) | 29 | ||
| DSY544 | C. albicans | Related to DSY775 | WT | 32 | |
| DSY775 | C. albicans | ERG11 (G464S), TAC1 (G980W) | 32 | ||
| DSY2309 | C. albicans | Related to DSY750 and DSY751 | WT | 33 | |
| DSY750 | C. albicans | MRR1 (N378D)b | 33 | ||
| DSY751 | C. albicans | ERG11 (S405F), MRR1 (N378D)b | 33 | ||
| DSY2243 | C. albicans | Related to DSY2242 | ERG11 (S442F, R467K) | 32 | |
| DSY2242 | C. albicans | ERG11 (S442F, R467K), TAC1 (G980E) | 32 | ||
| DSY2284 | C. albicans | Related to DSY2285 | WT | 15, 36 | |
| DSY2285 | C. albicans | MRR1 (T896I), i (5L) | 15, 36 | ||
| DSY550 | C. albicans | Related to DSY551 | WT | 15 | |
| DSY551 | C. albicans | ERG11 (G464S, Y132H) | 33 | ||
| DSY520 | C. albicans | Related to DSY522 | TAC1 (N972D) | 32 | |
| DSY522 | C. albicans | ERG11 (G464S), TAC1 (N972D) | 32 | ||
| DSY2250 | C. albicans | Related to DSY2250 | ERG11 (S442F, G465S) | 32 | |
| DSY2251 | C. albicans | ERG11 (S442F, G465S), TAC1 (N972D) | 32 | ||
| DSY741 | C. albicans | Related to DSY742 | WT | 33 | |
| DSY742 | C. albicans | MRR1 (T360I) | 33–35 | ||
| DSY562 | C. glabrata | WT | 33 | ||
| DSY565 | C. glabrata | DSY562 | CgPDR1 (I280F) | 33–35 | |
| DSY1041 | C. glabrata | DSY1029 | Cgcdr1Δ | 34 | |
| DSY1612 | C. glabrata | DSY1029 | Cgcdr2Δ | 34 | |
| DSY1613 | C. glabrata | DSY1056 | Cgcdr1Δ, Cgcdr2Δ | 34 | |
| DSY529 | C. glabrata | WT | 31 | ||
| DSY530 | C. glabrata | DSY529 | CgPDR1 (E1083Q) | 31 | |
| DSY2324 | C. glabrata | WT | 31 | ||
| DSY2325 | C. glabrata | DSY2324 | Mutation petite (loss of mitochondrial DNA) | 31 | |
| DSY724 | C. glabrata | WT | This study | ||
| DSY726 | C. glabrata | DSY724 | WT | 31 | |
| DSY727 | C. glabrata | DSY726 | CgPDR1 (D876Y) | 31 | |
| DSY2270 | C. glabrata | WT | 31 | ||
| DSY2271 | C. glabrata | DSY2270 | CgPDR1 (D261G) | 31 | |
| DSY759 | C. glabrata | WT | 31 | ||
| DSY2268 | C. glabrata | DSY759 | CgPDR1 (S316I) | 31 | |
a
Mutations are indicated in parentheses. Amino acid changes at given codon numbers of the corresponding gene are given. i (5L), isochromosome 5L.
b
Heterozygous state.
c
Deletion of methionine at position 677 in TAC1.