TABLE 5.
Activity of azoles in C. albicans clinical isolates with known resistance mechanisms
| C. albicans clinical strain | Resistance mechanism/genotype | MIC (μg/ml [fold differenceb]) |
||||
|---|---|---|---|---|---|---|
| Fluconazole | Itraconazole | Posaconazole | Voriconazole | Isavuconazole | ||
| DSY281 | WT | 0.250 (1) | 0.125 (1) | 0.031 (1) | 0.004 (1) | 0.016 (1) |
| DSY284 | ERG11 (S405F), TAC1 (G980E)a | 8 (32) | 0.25 (2) | 0.25 (8) | 0.063 (16) | 0.25 (16) |
| DSY347 | WT | 0.250 (1) | 0.125 (1) | 0.125 (1) | 0.004 (1) | 0.031 (1) |
| DSY288 | ERG11 (S405F) | 0.5 (2) | 0.125 (1) | 0.125 (1) | 0.031 (8) | 0.063 (2) |
| DSY289 | ERG11 (S405F, Y132H), TAC1 (A736V) | >128 (512) | 2 (16) | 0.5 (4) | 4 (1026) | 8 (256) |
| DSY348 | ERG11 (S405F), TAC1 (A736V) | 8 (32) | 1 (8) | 0.5 (4) | 0.063 (16) | 1 (32) |
| DSY290 | WT | 0.500(1) | 0.063 (1) | 0.063 (1) | 0.004 (1) | 0.008 (1) |
| DSY291 | ERG11 (G464S, R467K) | 2 (1) | 0.25 (4) | 0.063 (1) | 0.031 (8) | 0.031 (4) |
| DSY292 | ERG11 (G464S, R467K, Y132H),a MRR1 (P683H)a | 128 (256) | 1 (16) | 0.25 (4) | 0.5 (128) | 2 (256) |
| DSY294 | WT | 0.5 (1) | 0.016 (1) | 0.063 (1) | 0.004 (1) | 0.016 (1) |
| DSY296 | ERG11 (G464S), TAC1 (N977D) | 64 (128) | 0.125 (8) | 0.25 (4) | 0.5 (128) | 2 (128) |
| DSY2321 | ERG11 (S405F)a | <0.125 (1) | 0.031 (1) | 0.063 (1) | 0.004 (1) | <0.0039 (1) |
| DSY2322 | ERG11 (S405F), TAC1 (G980E) | 16 (128) | 1 (32) | 0.5 (8) | 0.125 (32) | 2 (513) |
| DSY2323 | ERG11 (S405F), TAC1 (G980E) | 32 (256) | 0.5 (16) | 0.5 (8) | 0.125 (32) | 2 (513) |
| DSY731 | WT | 0.250 (1) | 0.063 (1) | 0.031 (1) | 0.004 (1) | 0.008 (1) |
| DSY732 | TAC1 (ΔM677) | 16 (64) | 1 (16) | 0.5 (16) | 0.25 (64) | 4 (513) |
| DSY735 | TAC1 (ΔM677), i (5L) | 64 (256) | 0.5 (8) | 1 (32) | 0.25 (64) | 2 (256) |
| DSY544 | WT | 0.125 (1) | 0.063 (1) | 0.063 (1) | <0.0039 (1) | <0.0039 (1) |
| DSY775 | ERG11 (G464S), TAC1 (G980W) | 64 (512) | 1 (16) | 0.5 (8) | 0.5 (128) | 2 (513) |
| DSY2309 | WT | 2 (1) | 0.125 (1) | 0.125 (1) | 0.004 (1) | <0.0039 (1) |
| DSY750 | MMR1 (N378D)a | 16 (8) | 0.25 (2) | 0.125 (1) | 0.063 (16) | 0.063 (16) |
| DSY751 | ERG11 (S405F), MMR1 (N378D)a | 128 (64) | 0.5 (4) | 0.25 (2) | 0.125 (32) | 1 (256) |
| DSY2243 | ERG11 (S442F, R467K) | 0.25 (1) | 0.125 (1) | 0.063 (1) | 0.063 (1) | <0.0039 (1) |
| DSY2242 | ERG11 (S442F, R467K), TAC1 (G980E) | 8 (32) | 0.5 (4) | 0.5 (8) | 1 (16) | 1 (256) |
| DSY2284 | WT | 0.125 (1) | 0.063 (1) | 0.063 (1) | 0.004 (1) | 0.004 (1) |
| DSY2285 | MRR1 (T896I), i (5L) | 64 (512) | 0.25 (4) | 0.25 (4) | 0.125 (32) | 0.25 (64) |
| DSY550 | WT | 0.125 (1) | 0.016 (1) | 0.016 (1) | 0.004 (1) | 0.008 (1) |
| DSY551 | ERG11 (G464S, Y132H) | 64 (512) | 0.5 (32) | 0.5 (32) | 2 (513) | 2 (256) |
| DSY520 | TAC1 (N972D) | 16 (1) | 0.063 (1) | 0.5 (1) | 1 (1) | 0.250 (1) |
| DSY522 | ERG11 (G464S), TAC1 (N972D) | 128 (8) | 2 (32) | 1 (2) | 2 (2) | 2 (8) |
| DSY2250 | ERG11 (S442F, G465S) | 1 (1) | 0.125 (1) | 0.031 (1) | 0.004 (1) | 0.008 (1) |
| DSY2251 | ERG11 (S442F, G465S), TAC1 (N972D) | 32 (32) | 1 (8) | 4 (128) | 0.25 (64) | 4 (513) |
| DSY741 | WT | 0.125 (1) | 0.063 (1) | 0.125 (1) | 0.008 (1) | 0.008 (1) |
| DSY742 | MRR1 (T360I) | 16 (128) | 0.250 (4) | 0.125 (1) | 0.031 (4) | 0.125 (16) |
| DSY757 | WT | 0.5 (1) | 0.031 (1) | 0.063 (1) | <0.0039 (1) | <0.0039 (1) |
| DSY758 | ERG11 (G464S, F145L),a TAC1 (A736V) | 32 (64) | 0.5 (16) | 0.25 (4) | 0.125 (32) | 1 (256) |
a
Heterozygous state.
b
Fold difference is relative to the WT or to the most susceptible isolate for each related isolate group.