TABLE 6.
Activity of azoles in C. glabrata clinical isolates with known resistance mechanisms
| C. glabrata clinical strain | Resistance mechanism/genotype | MIC (μg/ml [fold differencea]) |
||||
|---|---|---|---|---|---|---|
| Fluconazole | Itraconazole | Posaconazole | Voriconazole | Isavuconazole | ||
| DSY562 | WT | 2 (1) | 1 (1) | 0.5 (1) | 0.25 (1) | 0.5 (1) |
| DSY565 | CgPDR1 (I280F) | 64 (32) | 4 (4) | 2 (4) | 1 (4) | 16 (32) |
| DSY1041 | Cgcdr1Δ | 2 (1) | 1 (1) | 0.5 (1) | 0.0312 (0.12) | 1 (2) |
| DSY1612 | Cgcdr2Δ | 32 (16) | 1 (1) | 1 (2) | 0.5 (2) | 8 (16) |
| DSY1613 | Cgcdr1Δ, Cgcdr2Δ | 1 (0.5) | 0.0312 (0.03) | 0.125 (0.25) | 0.0156 (0.06) | 0.25 (0.5) |
| DSY529 | WT | 4 (1) | 1 (1) | 0.5 (1) | 0.0312 (1) | 0.5 (1) |
| DSY530 | CgPDR1 (E1083Q) | 64 (16) | 2 (2) | 2 (4) | 0.5 (32) | 8 (16) |
| DSY2324 | WT | 2 (1) | 1 (1) | 0.25 (1) | 0.0312 (1) | 0.25 (1) |
| DSY2325 | Mutation petite | 128 (64) | 2 (0.5) | 2 (8) | 1 (32) | 8 (32) |
| DSY724 | WT | 4 (1) | 0.5 (1) | 1 (1) | 0.0625 (1) | 1 (1) |
| DSY726 | WT | 2 (0.5) | 0.25 (0.5) | 0.5 (0.5) | 0.0312 (0.5) | 0.25 (0.25) |
| DSY727 | CgPDR1 (D876Y) | 128 (32) | 8 (16) | 4 (4) | 1 (16) | 16 (16) |
| DSY2270 | WT | 4 (1) | 1 (1) | 1 (1) | 0.0625 (1) | 1 (1) |
| DSY2271 | CgPDR1 (D261G) | 128 (32) | 16 (16) | 16 (16) | 2 (32) | 16 (16) |
| DSY759 | WT | 4 (1) | 1 (1) | 1 (1) | 0.0312 (1) | 1 (1) |
| DSY2268 | CgPDR1 (S316I) | 64 (16) | 4 (4) | 4 (4) | 0.5 (16) | 8 (8) |
a
Fold difference relative to the level for the WT for each related isolate group.