TABLE 7.
Activity of azoles in C. albicans multidrug transporter mutants
C. albicans transporter mutant | Resistance mechanism/genotype | MIC (μg/ml) |
||||
---|---|---|---|---|---|---|
Fluconazole | Itraconazole | Posaconazole | Voriconazole | Isavuconazole | ||
CAF2-1 | URA3/ura3Δ | 0.25 | 0.0625 | 0.0625 | <0.0039 | 0.0078 |
DSY448 | cdr1Δ/Δ | <0.0625 | 0.0625 | 0.0625 | <0.0039 | <0.001 |
DSY465 | mdr1Δ/Δ | 0.25 | 0.0625 | 0.0625 | <0.0039 | 0.0078 |
DSY468 | cdr1Δ/Δ mdr1Δ/Δ | <0.0625 | 0.0625 | 0.0156 | <0.0039 | <0.001 |
DSY653 | cdr2Δ/Δ | 0.125 | 0.0625 | 0.0156 | <0.0039 | 0.0078 |
DSY654 | cdr1Δ/Δ cdr2Δ/Δ | <0.0625 | 0.0156 | 0.0156 | <0.0039 | 0.002 |
DSY1054 | flu1Δ/Δ | 0.25 | 0.0625 | 0.0625 | <0.0039 | 0.0156 |
DSY1021 | cdr1Δ/Δ cdr2Δ/Δ flu1Δ/Δ | <0.0625 | 0.0625 | 0.0625 | <0.0039 | <0.001 |
DSY1024 | cdr1Δ/Δ cdr2Δ/Δ flu1Δ/Δ mdr1Δ/Δ | <0.0625 | 0.0156 | 0.125 | <0.0039 | <0.001 |
DSY1050 | cdr1Δ/Δ cdr2Δ/Δ mdr1Δ/Δ | <0.0625 | 0.0156 | 0.0312 | <0.0039 | 0.002 |
DSY1055 | flu1Δ/Δ mdr1Δ/Δ | 0.25 | 0.0156 | 0.125 | <0.0039 | 0.0156 |