TABLE 8.

Activity of azoles in C. albicans mutants reconstituting the azole-susceptible parent

C. albicans ERG11/TAC1 mutant	Resistance mechanism/genotype	MIC (μg/ml [fold differencea])
		Fluconazole	Itraconazole	Posaconazole	Voriconazole	Isavuconazole
DSY294	WT	0.5 (1)	0.0156 (1)	0.0156 (1)	<0.0039 (1)	0.0156 (1)
DSY296	ERG11 (G464S), TAC1 (N977D)	64 (128)	0.125 (8)	0.25 (16)	0.5 (128)	2 (128)
DSY3082	ERG11, tac1Δ/Δ	0.5 (1)	0.0156 (1)	0.0156 (1)	0.0078 (2)	0.0312 (2)
DSY3083	ERG11 (G464S), tac1Δ/Δ	4 (8)	0.0078 (0.5)	0.0312 (2)	0.0156 (4)	0.0312 (2)
DSY3706	tac1Δ/Δ, ERG11	0.25 (0.5)	0.0156 (1)	0.0156 (1)	<0.0039 (1)	0.0156 (1)
DSY3606-1	tac1Δ/Δ, ERG11, TAC1-5 (N977D)	8 (32)	0.125 (4)	0.0625 (4)	0.0625 (16)	0.5 (64)
DSY3608-2	tac1Δ/Δ, ERG11, TAC1-1	0.125 (0.5)	0.0312 (1)	0.0156 (1)	<0.0039 (1)	0.0156 (2)
DSY3604	tac1Δ/Δ, ERG11 (G464S)b	0.5 (1)	0.0312 (2)	0.0312 (2)	0.0078 (2)	0.0078 (0.5)

^aFold difference relative to the level of the WT for each azole.

^bHeterozygous state.