TABLE 4.
Final population pharmacokinetic estimates and bootstrap results for ceftriaxone plasma concentrations and dried blood spot-derived plasma concentration for 10 healthy volunteers
| Parameter and/or modela | Value in plasma |
Value in DBS-derived plasma |
P value | ||||
|---|---|---|---|---|---|---|---|
| Mean | RSE (%)b | Bootstrap median (95% CI) | Mean | RSE (%) | Bootstrap median (95% CI) | ||
| Objective function value | −170.155 | −176.526 (−201.801 to −162.576) | −102.657 | −110.603 (−137.205 to −94.312) | |||
| Structural model parameters | |||||||
| CL/F (liters/h/70 kg) | 0.976 | 4 | 0.976 (0.902 to 1.06) | 0.974 | 7 | 0.966 (0.844 to 1.11) | 0.442 |
| VC/F (liters/70 kg) | 5.49 | 8 | 5.48 (4.65 to 6.55) | 5.93 | 9 | 5.88 (5.04 to 7.15) | 0.331 |
| Q/F (liters/h/70 kg) | 3.07 | 18 | 3.10 (1.63 to 4.03) | 2.36 | 44 | 2.40 (0.87 to 4.67) | 0.488 |
| VP/F (liters/70 kg) | 4.18 | 8 | 4.18 (3.38 to 4.77) | 4.23 | 16 | 4.26 (3.14 to 6.11) | 0.274 |
| Variable model parameters (shrinkage %) | |||||||
| IIV in CL/F (%) | 12 (1) | 19 | 11 (6 to 16) | 16 (6) | 24 | 15 (7 to 24) | 0.176 |
| IIV in VC/F (%) | 14 (4) | 13 | 14 (9 to 18) | 16 (13) | 28 | 17 (3 to 24) | 0.499 |
| r (CL/F, VC/F) | 0.874 | 31 | 0.901 (0.612 to 1.00) | 0.865 | 0.944 (−0.999 to 1.00) | ||
| RV for ceftriaxone (%) | 8 (16) | 14 | 8 (6 to 9) | 18 | 11 | 17 (12 to 21) | <0.001 |
a
CL/F, clearance relative to bioavailability; VC/F, central volume of distribution relative to bioavailability; Q/F, intercompartmental clearance; VP/F, peripheral volume of distribution relative to bioavailability; IIV, interindividual variability; RV, residual variability. IOV and IIV are presented as 100% × variability estimate.
b
RSE, relative standard error.