TABLE 2.
Lung CFU counts assessed during treatment and proportion of mice relapsing after treatment completion in experiment 1
| Drug regimen | Mean (±SD) log10 CFU count ata: |
Proportion (%) relapsing after treatment for: |
||||||
|---|---|---|---|---|---|---|---|---|
| D13 | D0 | M1 | M2 | M3 | 2 mo | 3 mo | 4 mo | |
| Untreated | 2.69 ± 0.13 | 6.17 ± 0.27 | 6.47 ± 0.06 | |||||
| 2RIF+INH+PZA/RIF+INH | 3.47 ± 0.37 | 1.59 ± 0.25 | 0.50 ± 0.51 | 13/15 (87) | 1/20 (5) | |||
| BDQ | 3.24 ± 0.25 | |||||||
| PMD | 4.57 ± 0.22 | |||||||
| LZD | 4.97 ± 0.26 | |||||||
| SZD | 3.85 ± 0.37 | |||||||
| BDQ+PMD | 4.21 ± 0.40 | 1.62 ± 0.19 | 0.52 ± 0.36 | 15/15 (100) | 10/15 (60) | 2/20 (10) | ||
| BDQ+LZD | 2.82 ± 0.15 | 1.91 ± 0.66 | ||||||
| BDQ+SZD | 2.88 ± 0.07 | 0.65 ± 0.50 | ||||||
| PMD+LZD | 3.23 ± 0.41 | 1.48 ± 0.12 | ||||||
| PMD+SZD | 1.65 ± 0.33 | 0.23 ± 0.40 | ||||||
| BDQ+PMD+LZD | 3.28 ± 0.65 | 0.34 ± 0.41 | 0.00 ± 0.00 | 12/15 (80) | 0/14 (0) | 0/20 (0) | ||
| BDQ+PMD+SZD | 0.94 ± 0.14 | 0.00 ± 0.00 | 14/20 (70) | 1/14 (7) | ||||
a
Time points are shown in days (e.g., D13, day 13; D0, day 0) or months (e.g., M1, 1 month) of treatment.