TABLE 3.
Lung CFU counts assessed during treatment and proportion of mice relapsing after treatment completion in experiment 2
| Regimen | Mean (±SD) log10 CFU count ata: |
Proportion (%) relapsing after treatment for: |
||||
|---|---|---|---|---|---|---|
| D13 | D0 | M1 | M2 | 1.5 mo | 2 mo | |
| Untreated | 4.42 ± 0.15 | 7.92 ± 0.26 | ||||
| RIF+INH+PZA | 2.06 ± 0.37 | |||||
| BDQ+PZA+PMD50 | 2.91 ± 0.33 | 0.95 ± 0.38 | ||||
| BDQ+PZA+PMD100 | 2.93 ± 0.31 | 0.06 ± 0.13 | 9/15 (60) | 1/15 (7) | ||
| 1BDQ+PZA+PMD100+LZD/1BDQ+PZA+PMD100 | 0.11 ± 0.24 | 0/15 (0) | 0/15 (0) | |||
| BDQ+PZA+PMD100+LZD | 0/15 (0) | 1/15 (7) | ||||
a
Time points are shown in days (e.g., D13, day 13; D0, day 0) or months (e.g., M1, 1 month) of treatment.