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Histogram illustrating the uniform activity of ASP2397 (EUCAST MICs are shown above the x axis) across wild-type and azole-resistant A. fumigatus isolates compared to that of itraconazole (shown below the x axis). The strains are named according to the genotype, with “wt” indicating the wild-type strain versus the strains harboring different CYP51A alterations at position G54, M220, or TR/L98H. Reference strains are indicated with official strain numbers preceded by “EUCAST” or “CLSI.”
