TABLE 1.
MIC and average recoveries of organisms by meropenem concentrationb
| Organism ID | Meropenem MIC (μg/ml)a | Avg no. of CFU on MHA with no antibiotics | % recovery (P value) with indicated concn (μg/ml) of meropenem |
||||
|---|---|---|---|---|---|---|---|
| 0.5 | 1 | 2.5 | 5 | 10 | |||
| ATCC BAA-2146 (NDM) | >32 | 83 | 123 (0.245) | 113 (0.322) | 96 (0.745) | 6 (0.008) | 0 (0.008) |
| NDM-CO-1 | >32 | 121 | 98 (0.880) | 99 (0.911) | 3 (0.001) | 0 (0.002) | 0 (0.002) |
| NDM-CO-2 | >32 | 92 | 112 (0.150) | 110 (0.140) | 96 (0.606) | 3 (0.001) | 0 (0.002) |
| NDM-CO-3 | >32 | 100 | 111 (0.319) | 84 (0.210) | 2 (0.006) | 0 (0.007) | 0 (0.007) |
| NDM-CO-4 | >32 | 104 | 96 (0.694) | 53 (0.017) | 0 (0.005) | 0 (0.005) | 0 (0.005) |
| NDM-CO-5 | >32 | 78 | 103 (0.818) | 116 (0.222) | 125 (0.162) | 120 (0.120) | 123 (0.088) |
| Env. KP NDM | >32 | 134 | 98 (0.648) | 100 (0.940) | 68 (0.005) | 0 (0.002) | 0 (0.002) |
| Env. EC NDM | 24 | 101 | 91 (0.185) | 84 (0.129) | 1 (0.001) | 0 (0.001) | 0 (0.001) |
| Utah NDM | >32 | 68 | 98 (0.605) | 91 (0.170) | 0 (<0.001) | 0 (<0.001) | 0 (<0.001) |
| KPC-R-1 | >32 | 52 | 103 (0.625) | 97 (0.808) | 106 (0.552) | 69 (0.372) | 76 (0.036) |
| KPC-R-2 | 8 | 53 | 0 (0.012) | 0 (0.012) | 0 (0.012) | 0 (0.012) | 0 (0.012) |
| KPC-CO-1 | 8 | 53 | 42 (0.016) | 0 (0.010) | 0 (0.010) | 0 (0.010) | 0 (0.010) |
| KPC-CO-2 | >32 | 67 | 120 (0.086) | 103 (0.818) | 11 (<0.001) | 20 (<0.001) | 2 (0.001) |
| KPC-CO-3 | 12 | 71 | 88 (0.140) | 92 (0.278) | 40 (0.030) | 8 (0.001) | 0 (0.003) |
| KPC-CO-4 | 16 | 66 | 85 (0.320) | 30 (0.049) | 0 (0.011) | 0 (0.011) | 0 (0.011) |
| KPC-CO-5 | 16 | 74 | 105 (0.584) | 99 (0.933) | 9 (0.007) | 16 (0.003) | 0 (0.006) |
a
MICs were determined by the meropenem Etest per the manufacturer's instructions.
b
ID, identifier; MHA, Mueller-Hinton agar; Env., environmental.