TABLE 2.
Magnitudes of avibactam exposures associated with stasis and bacterial killing of P. aeruginosa in lungs of mice for avibactam dosing regimens of q2h and q8h, codosed with ceftazidime at 16 mg/kg q2h
| Pneumoniaa | Strain | Ceftazidime MIC (mg/liter) | Avibactam dose (mg/kg) |
%fT>CT 1b |
||
|---|---|---|---|---|---|---|
| q2h | q8h | q2h | q8h | |||
| Stasis | 11 | 128 | 3.8 | 154.4 | 19.7 | 20.9 |
| 18 | 32 | 4.7 | 50.2 | 23.5 | 16.1 | |
| 1-log kill | 11 | 128 | 9.0 | 183.6 | 34.9 | 21.6 |
| 18 | 32 | 5.7 | 74.3 | 26.7 | 17.8 | |
| 2-log kill | 11 | 128 | 29.6 | 225.6 | 55.3 | 22.5 |
| 18 | 32 | 7.6 | 132.5 | 31.8 | 20.2 | |
a
Stasis, no growth of microorganisms compared to the initial inoculum; 1-log kill, 1-log10 kill of microorganisms compared to the initial inoculum.
b
CT, threshold concentration (virtual in vivo inhibitory concentration) in mg/liter; %fT>CT 1, percentage of time that free concentrations of avibactam stay above a CT of 1 mg/liter.