TABLE 3.
Magnitudes of avibactam %fT>CT associated with stasis and bacterial killing of P. aeruginosa in lungs of mice codosed with ceftazidime and various amounts of avibactam
| Strain | MIC (mg/liter) |
Ceftazidime dose (mg/kg) q2h | Avibactam %fT>CT 1b |
CAZ-AVI %fT>MICc | ||
|---|---|---|---|---|---|---|
| Ceftazidime | CAZ-AVIa | Stasis | 1-log kill | |||
| 1 | 128 | 8 | 32 | 0.0 | 0.0 | 34.6 |
| 5 | 128 | 8 | 64 | 19.4 | 20.6 | 49.3 |
| 7 | 64 | 4 | 16 | 21.4 | 22.4 | 63.5 |
| Median | 19.4 | 20.6 | 49.3 | |||
| Mean | 13.6 | 14.3 | 49.1 | |||
| SD | 11.8 | 12.4 | 14.5 | |||
MIC of ceftazidime measured with a fixed avibactam concentration of 4 mg/liter.
Stasis, no growth of microorganisms compared to the initial inoculum; 1-log kill, = 1-log10 kill of microorganisms compared to the initial inoculum; CT, threshold concentration (virtual in vivo inhibitory concentration) in mg/liter; %fT > CT 1, percentage of time that free concentrations of avibactam stay above a CT of 1 mg/liter.
Percentage of time that free concentrations of ceftazidime stay above the MIC of CAZ-AVI (the MIC of ceftazidime as determined in the presence of a fixed avibactam concentration of 4 mg/liter).