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. 2016 Jan 7;7:2. doi: 10.1186/s13287-015-0264-1

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© Chen et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Noggin treatment only during OPA1 ^+/−-iPSC differentiation into neural rosettes could rescue OPA1 ^+/−-RGC generation. Control and VO-iPSCs were incubated with 100 ng/mL Noggin in the cell culture medium only during the differentiation of neural rosettes and Noggin was removed in afterward differentation. Cells were fixed with 4 % PFA on day 31. Upper panel, TUJ1 (green) and BRN3a (red) staining are shown. Lower panel, TUJ1 (green) and ISLET-1 (red) staining are shown. Scale bars = 100 μM. Data from the control under the same treatment are not shown