Table 4.
Genotype of DNA repair genes and associations with lung cancer risk
| SNPs | Lung cancer n(%) | Controls n(%) | OR† | Pvalue |
|---|---|---|---|---|
| XRCC1 | ||||
| rs25487 | ||||
| GG | 142 (56.6) | 145 (48.2) | Reference | |
| AG | 95 (37.8) | 126 (41.9) | 0.74 (0.50–1.09) | 0.131 |
| AA | 14 (5.6) | 30 (10.0) | 0.52 (0.25–1.07) | 0.077 |
| Any A | 109 (43.4) | 156 (51.8) | 0.70 (0.48–1.01) | 0.058 |
| A MAF | 0.25 | 0.31 | ||
| rs1799782 | ||||
| CC | 138 (55.0) | 155 (51.5) | Reference | |
| CT | 90 (35.9) | 119 (39.5) | 0.82 (0.55–1.22) | 0.33 |
| TT | 23 (9.2) | 27 (9.0) | 0.95 (0.49–1.83) | 0.87 |
| Any T | 113 (45.0) | 146 (48.5) | 0.85 (0.58–1.22) | 0.37 |
| T MAF | 0.27 | 0.29 | ||
| .rs3213334 | ||||
| CC | 206 (82.1) | 243 (80.7) | Reference | |
| CT | 44 (17.5) | 55 (18.3) | 0.95 (0.59–1.54) | 0.85 |
| TT | 1 (0.4) | 3 (1.0) | 0.89 (0.09–8.68) | 0.92 |
| Any T | 45 (17.9) | 58 (19.3) | 0.95 (0.59–1.53) | 0.84 |
| T MAF | 0.09 | 0.10 | ||
| XPA | ||||
| rs3176720 | ||||
| AA | 202 (80.5) | 250 (83.1) | Reference | |
| AC | 48 (19.1) | 48 (15.9) | 1.38 (0.85–2.23) | 0.196 |
| CC | 1 (0.4) | 3 (1.0) | 0.36 (0.03–4.02) | 0.404 |
| Any C | 49 (19.5) | 51 (16.9) | 1.31 (0.81–2.10) | 0.270 |
| C MAF | 0.10 | 0.09 | ||
| .rs2808668 | ||||
| CC | 49 (19.5) | 93 (30.9) | Reference | |
| CT | 142 (56.6) | 139 (46.2) | 1.77 (1.12–2.80) | 0.014 |
| TT | 60 (23.9) | 69 (22.9) | 1.43 (0.84–2.43) | 0.194 |
| Any T | 202 (80.5) | 208 (69.1) | 1.66 (1.08–2.55) | 0.022 |
| T MAF | 0.52 | 0.46 | ||
| XPC | ||||
| .rs2229090 | ||||
| CC | 116 (46.2) | 152 (50.5) | Reference | |
| CG | 109 (43.4) | 114 (37.9) | 1.33 (0.90–1.97) | 0.157 |
| GG | 26 (10.4) | 35 (11.6) | 1.06 (0.57–1.99) | 0.848 |
| Any G | 135 (53.8) | 149 (49.5) | 1.27 (0.88–1.84) | 0.209 |
| G MAF | 0.32 | 0.31 | ||
| .rs2228001 | ||||
| AA | 96 (38.2) | 113 (37.5) | Reference | |
| AC | 116 (46.2) | 137 (45.5) | 1.12 (0.74–1.68) | 0.595 |
| CC | 39 (15.5) | 51 (16.9) | 0.88 (0.51–1.53) | 0.653 |
| Any C | 155 (61.8) | 188 (62.5) | 1.05 (0.72–1.54) | 0.805 |
| C MAF | 0.39 | 0.40 | ||
| . rs2733533 | ||||
| CC | 215 (85.7) | 283 (94.0) | Reference | |
| AC | 36 (14.3) | 18 (6.0) | 2.48 (1.29–4.76) | 0.006 |
| AA | 0 (0.0) | 0 (0.0) | – | – |
| Any A | 36 (14.3) | 18 (6.0) | 2.48 (1.29–4.76) | 0.006 |
| AA MAF | 0.07 | 0.03 | ||
| .rs3729584 | ||||
| GG | 135 (53.8) | 147 (48.8) | Reference | |
| AG | 96 (38.2) | 126 (41.9) | 0.72 (0.48–1.06) | 0.099 |
| AA | 20 (8.0) | 28 (9.3) | 0.81 (0.41–1.60) | 0.552 |
| Any A | 116 (46.2) | 154 (51.2) | 0.73 (0.51–1.07) | 0.104 |
| AA MAF | 0.27 | 0.30 | ||
| XPD | ||||
| rs1799787 | ||||
| CC | 203 (80.9) | 260 (86.4) | Reference | |
| CT | 47 (18.7) | 37 (12.3) | 1.89 (1.13–3.15) | 0.015 |
| TT | 1 (0.4) | 4 (1.3) | 0.09 (0.009–1.00) | 0.050 |
| Any T | 48 (19.1) | 41 (13.6) | 1.63 (0.99–2.68) | 0.055 |
| T MAF | 0.10 | 0.07 | ||
| .rs238415 | ||||
| CC | 76 (30.3) | 90 (29.9) | Reference | |
| CG | 127 (50.6) | 138 (45.8) | 1.07 (0.69–1.64) | 0.772 |
| GG | 48 (19.1) | 73 (24.3) | 0.70 (0.42–1.19) | 0.192 |
| Any G | 175 (69.7) | 211 (70.1) | 0.94 (0.63–1.41) | 0.761 |
| G MAF | 0.44 | 0.47 |
†
OR: adjusted for age, gender and smoking status (pack-year) using unconditional logistic regression.
SNPs, single nucleotide polymorphisms.