Table 6.
Associations between frequencies of DNA repair gene haplotypes and lung cancer risk
| Haplotypes | Lung cancer n(%) | Controls n(%) | OR††(95% CI) | Pvalue |
|---|---|---|---|---|
| XRCC1† | ||||
| ACC | 122 (24.3) | 185 (30.7) | Reference | |
| GCC | 198 (39.4) | 184 (30.6) | 1.63 (1.17–2.28) | 0.004 |
| GTC | 135 (26.9) | 171 (28.4) | 1.18 (0.83–1.68) | 0.357 |
| Others | 47 (9.4) | 62 (10.3) | 1.23 (0.76–2.00) | 0.397 |
| XPA‡ | ||||
| AC | 240 (47.8) | 325 (54.0) | Reference | |
| AT | 212 (42.2) | 223 (37.0) | 0.77 (0.49–1.21) | 0.258 |
| CT | 50 (10.0) | 54 (9.0) | 0.92 (0.58–1.45) | 0.709 |
| XPC§ | ||||
| CCCG | 171 (34.1) | 211 (35.0) | Reference | |
| CACA | 135 (26.9) | 181 (30.1) | 1.12 (0.81–1.55) | 0.483 |
| GACG | 134 (26.7) | 156 (25.9) | 1.32 (0.83–2.08) | 0.238 |
| Others | 62 (12.4) | 54 (9.0) | 1.21 (0.86–1.71) | 0.284 |
| XPD¶ | ||||
| CG | 223 (44.4) | 284 (47.2) | Reference | |
| CC | 230 (45.8) | 273 (45.3) | 0.89 (0.68–1.16) | 0.374 |
| TC | 49 (9.8) | 45 (7.5) | 1.24 (0.77–1.99) | 0.379 |
†
XRCC1: rs25487- rs1799782 -rs3213334.
‡
XPA: rs3176720-rs2808668.
§
XPC: rs2229090-rs2228001-rs2733533-rs3729584.
¶
XPD: rs1799787-rs238415.
††
OR: adjusted for age, gender, smoking status.
CI, confidence interval; OR, odds ratio.