Table 1.
Main clinicopathological findings of previously reported cases of primary lung carcinoma with osteoclast-like giant cells
| Case No. | Age/Gender | Location | Size (cm) | Histology of main lung carcinoma | Immunohistochemistry of osteoclast-like giant cells | Metastasis of lung carcinoma | Outcome | |
|---|---|---|---|---|---|---|---|---|
| Surgery | Autopsy | |||||||
| 11 | 57/M | RLL | 4.5 | Squamous cell carcinoma | Not done | None | – | 5 years, ANED |
| 22 | 60/M | RLL | 3 | Squamous cell carcinoma | Lyso- | – | Present§ | 7 days, DOD |
| 33 | 60/F | RLL | 9 | Undifferentiated carcinoma† | Not done | None | Present§ | 75 days, DOD |
| 44 | 61/M | LUL | 6 | Squamous cell carcinoma | CK-/EMA-/CEA-/CD68+/vim+/S-100- | None | – | 15 months, ANED |
| 55 | 67/M | Unknown | 6.5 | Sarcomatoid carcinoma | CK‡-/EMA-/CD68+/vim+ | None | Unknown | 19 months, DOD |
| 65 | 61/F | Unknown | 1.5 | Sarcomatoid carcinoma† | CK‡-/EMA-/CD68+/vim+ | None | Unknown | 12 months, DOD |
| 75 | 75/F | Unknown | 1.1 | Adenocarcinoma | CK‡-/EMA-/CD68+/vim+ | None | – | 19 months, AWD |
| 86 | 58/M | RUL | 1.4 | Large cell carcinoma | CAM5.1-/CD68+ | Present§ | Unknown | Unknown |
†
Also containing foci of adenocarcinoma.
‡
Including keratin AE1/AE3, keratin MAK6, and keratin CAM5.2.
§
Metastatic lesions also containing osteoclast-like giant cells. ANED, alive with no evidence of disease; AWD, alive with disease; ca, carcinoma; CK, cytokeratin; DOD, dead of disease; EMA, epithelial membrane antigen; Lyso, lysozyme; LUL, left upper lobe; RLL, right lower lobe; RUL, right upper lobe; S-100, S-100 protein; vim, vimentin.