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. 2016 Jan 7;15:13. doi: 10.1186/s12936-015-1045-0

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© Shah et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — G6PD trait association tests—estimated odds ratios. Results from association tests using a composite G6PD genotype to infer G6PD deficiency trait status, where composite genotype is the total number of variant alleles present across all three deficiency SNPs (A968G, T542A, and C202T) in an individual (‘G6PD trait’). Presence or absence of full expression of the trait (i.e. full G6PD enzyme deficiency) was also tested, where presence of the ‘full’ expression of the trait required presence of one (male hemizygotes) or two (female homozygotes) deficiency alleles in total across the three loci (‘G6PD trait [full]’). Also shown are association test results for HbS (red). Estimated OR with 95 % CI is shown for association with severe malaria overall (ALL), as well as for each subphenotype (SMA, CM)