Table 4.

Gender-stratified tests of association

Male (hemizygotes)	Frequency		ALL		SMA		CM
	Control	Case (SMA, CM)	OR (95 % CI)	P value	OR (95 % CI)	P value	OR (95 % CI)	P value
	N = 1941	N = 1301 (309, 478)
A968G	0.073	0.050 (0.084, 0.046)	0.70 (0.51–0.95)	0.0235	1.19 (0.72–1.95)	0.4961	0.62 (0.37–1.05)	0.0772
T542A	0.011	0.009 (0.026, 0.003)	0.84 (0.40–1.80)	0.6625	2.55 (1.00–6.52)	0.0505	0.28 (0.04–2.11)	0.2167
C202T	0.032	0.026 (0.042, 0.028)	0.87 (0.56–1.34)	0.5256	1.36 (0.68–2.72)	0.3834	0.94 (0.49–1.83)	0.8628
G6PD trait	0.118	0.087 (0.155, 0.079)	0.75 (0.58–0.96)	0.0231	1.41 (0.96–2.08)	0.0832	0.67 (0.45–1.02)	0.0608

Female (heterozygotes)	Frequency		ALL		SMA		CM
	Control	Case (SMA, CM)	OR (95 % CI)	P value	OR (95 % CI)	P value	OR (95 % CI)	P value
	N = 1895	N = 1078 (247, 412)
A968G	0.120	0.112 (0.148, 0.086)	0.87 (0.68–1.11)	0.2656	1.14 (0.74–1.76)	0.5654	0.63 (0.42–0.95)	0.0285
T542A	0.026	0.012 (0.022, 0.012)	0.43 (0.23–0.80)	0.0084	0.71 (0.25–2.03)	0.5244	0.41 (0.15–1.16)	0.0942
C202T	0.063	0.039 (0.048, 0.029)	0.67 (0.46–0.97)	0.0355	0.83 (0.41–1.69)	0.6065	0.49 (0.25–0.95)	0.0345
G6PD trait	0.202	0.160 (0.212, 0.124)	0.74 (0.60–0.91)	0.0045	0.99 (0.68–1.45)	0.9776	0.54 (0.38–0.77)	0.0006