Fig. 2.

Cumulative T2D-free survival by CLOCK-rs4580704 genotypes in non-T2D subjects at baseline depending on the dietary intervention group. a Mediterranean diet groups (n = 2477); and b control group (n = 1194). Cox regression models with outcome of T2D incidence by the CLOCK-rs4580704 SNP (CC versus carriers of the G-allele) were multivariable adjusted for each stratum and the corresponding hazard ratios (HR) and 95 % CI were obtained in the multivariable adjusted models. CC subjects were considered the reference category and HR for G-carriers versus CC were estimated. HR ¹ model adjusted for sex, age and field center. HR ² Models additionally adjusted for BMI, drinking, smoking, physical activity, medications and total energy intake at baseline. P for interaction between the CLOCK SNP (as dominant) with dietary intervention (MedDiet vs control group) = 0.052 in model 2