Table 2.
Incidence rate and hazard ratios (HR) for type-2 diabetes (T2D) depending on the CLOCK-rs4580704 in non-T2D subjects
| CLOCK genotypes | Non-T2D subjects at baseline (n = 3671) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | Person-y | Incidence ratea | Model 1 | Model 2 | |||||
| HR | 95 % CI | P value | HR | 95 % CI | P value | ||||
| Dominant model | |||||||||
| CC | 130 | 6088.5 | 21.4 | 1.00 | (Reference) | 1.00 | (Reference) | ||
| CG + GG | 156 | 10727.7 | 14.5 | 0.68 | (0.54–0.86) | 0.001 | 0.69 | (0.54–0.87) | 0.002 |
Model 1: adjusted for sex, age, center and dietary intervention group
Model 2: adjusted for variables in model 1 plus BMI, drinking, smoking, physical activity, medication (hypertension, dyslipemia and glucose), adherence to the Mediterranean Diet and total energy intake at baseline
aCrude incidence rates were expressed per 1000 person-years of follow-up