Table 3.
Treatment-related toxicities in patients with locoregionally advanced NPC treated with NAC plus IMRT vs. CCRT plus AC
| Toxicity | NAC + IMRT [cases (%)] |
CCRT + AC [cases (%)] |
χ 2 | P |
|---|---|---|---|---|
| Grade 3/4 acute toxicities | ||||
| Leukopenia | 1 (0.9) | 12 (9.8) | 7.618 | 0.006 |
| Anemia | 0 | 3 (2.4) | 1.252 | 0.263 |
| Thrombocytopenia | 1 (0.9) | 4 (3.3) | 0.719 | 0.397 |
| Hepatotoxicity | 0 | 1 (0.8) | 0.000 | 1.000 |
| Nausea–vomiting | 2 (1.7) | 10 (8.1) | 5.204 | 0.023 |
| Mucositis | 5 (4.3) | 8 (6.5) | 0.582 | 0.445 |
| Late toxicities | ||||
| Skin dystrophy | 37 (31.6) | 51 (41.5) | 2.500 | 0.114 |
| Subcutaneous fibrosis | 26 (22.2) | 29 (23.6) | 0.062 | 0.803 |
| Xerostomia | 68 (58.1) | 85 (69.1) | 3.132 | 0.077 |
| Hear loss | 54 (46.2) | 64 (52.0) | 0.829 | 0.363 |
| Temporal lobe injury | 4 (3.4) | 6 (4.9) | 0.059 | 0.809 |
Abbreviations as in Table 1