Table 1.
Location | Pailin, Cambodia | Pursat, Cambodia | Oddar Meanchey Province, Cambodia | Tasanh, Cambodia | Sudan and Uganda |
Reference | Leang et al. [16] | Leang et al. [16] | Spring et al. [17] | Bethell et al. [18] | Mukhtar et al. [19]a; Priotto et al. [20]b |
Drugs given | DHA-PQP | DHA-PQP | DHA-PQP | AS | AS + SP |
Percentage of treated individuals with slow parasite clearance | 32.2 % | 8.6 % | 54 % | 48.2 % | 3.5b % |
Slow parasite clearance time (days) | 8.91c | 6.04c | 10.26 | 10.86c | 5.42c |
Percentage of treated individuals that recrudesce to LCF | 2.7 % | 5.4 % | 21 % | 1.6d % | 3.9a % |
Percentage of individuals that recrudesce to LPF | 10.7 % | 0 % | 24 % | 4.8d % | 10.4a % |
Time to recrudesce (days) | 26.9 | 25.6 | 27.1 | 24.5e | 25.3a |
Summary | Medium artemisinin and partner drug resistance | Low artemisinin and partner drug resistance | High artemisinin and partner drug resistance | High artemisinin resistance | No artemisinin resistance and high partner drug resistance |
a,bDenotes which study each value was obtained (a = Mukhtar et al. [19], b = Priotto et al. [20])
cThese values were not given in the studies and were derived from data—see Additional file 1: Supplementary methods for details
dValues not given in paper, only total proportion of people recrudescing (6.4 %)—this was split up to match the LCF:LPF ratio from the 2010 Tasanh study
eNot given in paper, assumed to be same as 2010 Tasanh study