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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Immunol Rev. 2015 Mar;264(1):276–287. doi: 10.1111/imr.12273

Fig. 2. LTA4H genotype associates with disease severity in humans and zebrafish.

Fig. 2

A polymorphism in LTA4H is associated with increased severity of TB in humans. In zebrafish, both high- and low-activity LTA4H genotypes result in more severe disease, but for distinct reasons, with high-burden necrosis in the low inflammatory state and induction of necroptosis in the high inflammatory condition.