. Author manuscript; available in PMC: 2016 Jan 7.

Published in final edited form as: ACS Biomater Sci Eng. 2015 Oct 20;1(12):1300–1305. doi: 10.1021/acsbiomaterials.5b00356

Table 2.

In Vivo Hemostasis Response to SLac, Bax50, Gelfoam, and SB50^a

	no heparin			heparinized
	SLac	Bax50	SB50	SLac	Bax50	SB50	GelFoam^b	Puramatrix^b
time to hemostasis	11 s (±2 s)	no hemo-stasis	6 s (±1 s)	120 s (±5 s)	no hemo-stasis	5 s (±1 s)	no hemo-stasis	19 s (±2 s)
initial bleeding^c	++	++++	+	+++	+++++	++	++	++
postbleeding^c	+	++	none	++++	+++++	+	+++++	+++++
perturbed bleeding^c	+++	+++	none	+++++	+++++	none	+++++	+++++

Notation: + indicates degree of bleeding with + → marginal bleeding absorbable with gauze, +++ → moderate bleeding, and +++++ → profuse bleeding.

Gelfoam and Puramatrix (RADA16) are commercially available materials that are known to form a physical barrier for hemostasis.

Initial bleeding: bleeding measured during the 2 min period immediately after application of hemostat. Postbleeding: bleeding after manual wiping of excess hemostat from the wound site using sterile gauze. Perturbed bleeding: Bleeding of the wound site after manipulation with forceps.