Figure 4.

In homogeneities of spatial and temporal strains, distribution must be considered when designing an experiment using in vivo axial loading. (a) a typical shape of the mouse tibia (3D rendering of micro-computed tomography scan). The various bends of the tibia deflect forces under axial loading, resulting in an inhomogeneous spatial distribution of strains, as shown with finite-element models: Strains are distributed inhomogeneously over the tibia surface (b), but also within a single cross-section (c). (Bottom) Comparison between programmed waveform and the actual strains waveform measured locally (position of strain gage shown with *, as described in Akhter et al.17