Figure EV2. Frequency of TAD–TAD interactions at each tree level.

The average metaTAD inter‐domain, I (blue curves), and intra‐domain, J (magenta), interactions are shown as a function of the number of TADs, n, which a metaTAD includes in our three cell types (see also Appendix Supplementary Methods). The larger the domains considered, the lower their average interactions, consistently with Hi‐C results. As expected, intra‐domain interactions, J, stay always above inter‐domain interactions, I.