Figure 1. The synchronous network activity in the PFC is dependent on AMPAR‐ and NMDAR‐mediated glutamatergic transmission .

Network bursts recorded in PFC pyramidal neurons held at −70 mV (A) or −20 mV (B) in the absence or presence of DNQX (AMPAR antagonist), APV (NMDAR antagonist) or bicuculline (GABAAR antagonist). *Enlarged view of the network bursting‐associated currents. At −70 mV, the network burst is made of an inward excitatory current. At −20 mV, the network burst is composed of inward excitatory and outward inhibitory currents. C and D, synaptic currents recorded in PFC pyramidal neurons (held at −70 mV) from thin slices (100 μm) or medium spiny neurons (held at −70 mV) from striatal slices.