Figure 3. Activation of hD4.7 induces an over‐suppression of excitatory network activity and an under‐suppression of inhibitory network activity in the PFC .

Excitatory or inhibitory network burst amplitudes (A) and frequencies (B) showing the effect of PD168077 (20 μm) in PFC pyramidal neurons (held at −20 mV) of D₄R knockout mice with viral infection of human D4.4 or D4.7 variants. C, representative excitatory and inhibitory network bursts in the absence or presence of PD168077 in PFC pyramidal neurons from different groups. D, percentage reduction of the amplitude of excitatory or inhibitory network bursts by PD168077 in different groups. *P < 0.01, ANOVA. E, amplitude or frequency of baseline excitatory and inhibitory network bursts (held at −20 mV) in different groups.