Figure 2. Prolonged application of H₂O₂ results in an increase followed by depression in mEPSC frequency .

A, continuous chart recording of mEPSCs before, during and after H₂O₂ (1 mm, 15 min) superfusion. B, summary of mEPSC frequency data. Values are shown as percentage change relative to the control after 15 min of H₂O₂ superfusion (n = 7) and after washout (n = 6) (mean ± SEM). P values were determined by a paired t test. The holding potential was −70 mV for all recordings. Washout indicates the 10 min period after initiating H₂O₂ washout.