Table 2.
RSV PRN Titers and CMTRs by Placental Malaria Status and Hypergammaglobulinemia
| Maternal PRNT GM (range) | Cord PRNT GM (range) | CMTR GM (range) | Proportion of CMTRs <0.8 | Proportion of CMTRs <1.0 | |
|---|---|---|---|---|---|
| Alexishafen cohort | |||||
| All | 254.3 (11–7150) | 301.7 (21.4–3257) | 1.19 (0.22–4.54) | 0.17 | 0.34 |
| Placental malaria + | 220.4 (23–7150) | 256.0 (33–3257) | 1.16 (0.22–4.24) | 0.17 | 0.37 |
| Placental malaria − | 303.0 (11–3329) | 371.7 (21.4–3191) | 1.23 (0.32–4.54) | 0.17 | 0.32 |
| P = .02 | P = .007 | P = .8 | OR 1.04 [0.40–2.77] P = .9 | OR 1.24 [0.59–2.64] P = .53 | |
| Hypergammaglobulinemia + | 305.1 (11–7150) | 332.4 (21.4–3257) | 1.09 (0.22–4.55) | 0.22 | 0.42 |
| Hypergammaglobulinemia − | 205.1 (23–1973) | 269.1 (33–2870) | 1.31 (0.40–3.99) | 0.11 | 0.25 |
| P = .004 | P = .159 | P = .014 | OR 2.3 [0.88–6.5] P = .06 | OR 2.2 [1.05–4.66] P = .02 | |
| FIS cohort | |||||
| All | 239.1 (19.5–2259) | 291.0 (23.1–2592) | 1.22 (0.29–3.88) | 0.18 | 0.32 |
| Placental malaria + | 229.9 (58.7–587.9) | 300.9 (78.3–869.3) | 1.30 (0.71–2.55) | 0.08 | 0.25 |
| Placental malaria − | 246.0 (19.5–2259) | 295.2 (23.1–2592.8) | 1.2 (0.29–3.88) | 0.2 | 0.34 |
| P = .81 | P = .78 | P = .52 | OR 0.36 [0.008–2.74] P = .46 | OR 0.64 [0.11–2.73] P = .75 | |
| Hypergammaglobulinemia + | 368.5 (87.1–2032) | 353.2 (192.4–836) | 0.96 (0.41–2.58) | 0.50 | 0.67 |
| Hypergammaglobulinemia − | 229.8 (19.5–2259) | 285.9 (23.1–2598) | 1.24 (0.29–3.88) | 0.15 | 0.29 |
| P = .055 | P = .278 | P = .065 | OR 5.55 [1.31–22.7] P = .009 | OR 4.89 [1.2–23.3] P = .019 | |
Abbreviations: CMTRs, cord-to-maternal titer ratios; FIS, Fetal Immunity Study; GM, geometric mean; OR, odds ratio; PRNT, plaque-reduction neutralization titer; RSV, respiratory syncytial virus.