Figure 4.

Gene ontology (GO) analysis of 668-gene entities differentially expressed between the cured group and the tuberculosis-relapse group. A, GO analysis of the 668 gene entity list from the analysis of variance (Supplementary Table 2) was conducted in GeneSpring GX to grossly allocate function to the gene list. Biological processes are shown where they are overrepresented within the 668 gene entity list (P < .1). B, The same gene list was inputted into the Database for Annotation, Visualization, and Integrated Discovery (DAVID) functional annotation tool. A total of 506 entities were mapped to unique known genes in the DAVID database, and 23 biological process GO terms, containing ≥15 entities and with an EASE score of <0.05, were identified within the gene entity list. GO terms are shown clustered by function. Fold–enrichment values, showing overrepresentation of the term within the 506 gene list, are plotted as bars on the top axis; values calculated on the basis of 1 – [EASE score] are plotted as dots on the bottom axis.