Figure 4.

Structural mapping of escape mutations on the Hendra virus (HeV) and Nipah virus (NiV) attachment glycoprotein (G). The neutralization-escape mutations H406Y and D582N (A) and Q450K, V507I, and R516K (B) were mapped onto the structures of the HeV (A) and NiV strain Malaysia (NiV-M; B) attachment Gs (in blue), respectively. The changed amino acid residues are shown in red. The structure of ephrin B2 is shown in yellow. Residues involved in the interaction of G and ephrin B2 are shown as sticks in orange (on G) and yellow (on ephrin B2).