Figure 7.

Effect of neutralization escape on replication of henipaviruses in hamsters. Lung (black bar) and brain (white bar) titer results for hamsters infected with wild-type (WT) and neutralization-escape mutants of Hendra virus (HeV; A) and Nipah virus strain Malaysia (NiV-M; B) when moribund. Lung and brain tissues were harvested from infected hamsters when moribund and were assayed for infectious virus as described in “Materials and Methods” section. Tissue samples from 5 animals were analyzed. Error bars represent standard deviations. *P < .05 by 2-way analysis of variance, compared with the WT strain.