Representative herpes simplex virus type 2 (HSV-2) shedding patterns for 4 participants, by sex and human immunodeficiency virus (HIV) status. Black bars indicate lesions present, gray bars indicate no lesions present, and negative values indicate missing samples. A, Data for a 29-year-old HIV-seronegative man. B, Data for a 57-year-old HIV-seronegative woman. C, Data for a 33-year-old HIV-seropositive man with a CD4+ T-cell count of 273 cells/mm3 and a plasma HIV RNA load of 149 955 copies/mL. D, Data for a 49-year-old HIV-seropositive woman with a CD4+ T-cell count of 52 cells/mm3 and a plasma HIV RNA load of 290 575 copies/mL.