Table 2.
Genital Herpes Simplex Virus (HSV) Shedding and Lesion Outcomes in the Study Cohort
| HSV Outcome | Total Cohort (n = 93) | HIV-Seronegative Group |
HIV-Seropositive Group |
||
|---|---|---|---|---|---|
| Men (n = 11) | Women (n = 28) | Men (n = 20) | Women (n = 34) | ||
| HSV detection frequency | |||||
| Swabs per participant, no. | 125 (19–132) | 125 (124–132) | 126 (71–127) | 124 (19–129) | 125 (43–127) |
| Days sampled per participant, no. | 43 (7–45) | 43 (42–45) | 43 (24–43) | 43 (7–44) | 43 (15–44) |
| Participants with ≥1 swab with HSV detected | 87 (94) | 10 (91) | 26 (93) | 20 (100) | 31 (91) |
| Swabs with HSV detected | 2484 (22) | 418 (30) | 463 (13) | 811 (35) | 792 (19) |
| Days with HSV detected | 1169 (30) | 194 (41) | 236 (20) | 370 (46) | 369 (26) |
| Swabs with subclinical HSV detected | 1480 (16) | 263 (22) | 322 (11) | 343 (23) | 552 (16) |
| Days with subclinical HSV detected | 758 (24) | 133 (33) | 175 (17) | 183 (36) | 267 (22) |
| Lesion frequency | |||||
| Days with lesions reported | 749 (19) | 74 (16) | 171 (14) | 292 (36) | 212 (15) |
| Shedding episodes | |||||
| Episode rate per 30 d | |||||
| All episodes | 2.8 (0–10.4) | 4.2 (0–6.3) | 2.1 (0–7.6) | 4.2 (0.7–8.7) | 2.1 (0–10.4) |
| Subclinical episodes | 1.7 (0–8.3) | 2.8 (0–4.2) | 1.4 (0–7.1) | 2.1 (0–4.8) | 1.4 (0–8.3) |
| Episodes with ≥1 lesion-day | 0.7 (0–5.4) | 0.7 (0–2.8) | 0 (0–3.5) | 0.7 (0–5.4) | 0 (0–4.2) |
| Episode duration, h, median (IQR) | |||||
| All episodes | 22.5 (8.5–64.8) | 16.3 (8.5–64.4) | 15.6 (8.3–55.0) | 28.9 (12.9–123.9) | 19.9 (8.4–55.0) |
| Subclinical episodes | 14.7 (8.0–32.8) | 9.2 (8.0–24.5) | 10.4 (8.0–34.5) | 21.3 (8.6–32.2) | 15.3 (8.0–39.1) |
| Episodes with ≥1 lesion–day, no. | 100.6 (16.4–182.3) | 184.1 (16.5–272.0) | 47.4 (8.5–112.7) | 143.7 (25.3–175.9) | 55.2 (16.1–185.3) |
| HSV load, log10 copies/mLa | |||||
| Overall | 4.3 (2.2–8.9) | 4.4 (2.2–8.9) | 3.9 (2.2–8.5) | 4.9 (2.2–8.6) | 4.2 (2.2–8.2) |
| Subclinical episodes | 3.7 (2.2–8.7) | 3.6 (2.2–8.7) | 3.6 (2.2–8.5) | 3.6 (2.2–8.4) | 3.9 (2.2–7.8) |
| Lesional | 5.3 (2.2–8.9) | 5.6 (2.2–8.9) | 4.5 (2.3–8.5) | 6.3 (2.2–8.6) | 4.7 (2.2–8.2) |
Data are median value (range) or no. (%) of subjects, unless otherwise indicated.
Abbreviations: HIV, human immunodeficiency virus; IQR, interquartile range.
a Among samples with HSV detected.