Fig 3. Example dynamic sensitivity analysis of the mitotic cyclin synthesis parameter in the Barik model (k _s,bM).

(A) $C_k^{T_{div}}$ and $C_k^{V_{div}}$ for all parameters in the Barik model, with the parameter representing mitotic cyclin synthesis marked in green. (B) Sensitivity of V _dau and T _S/G2/M for four generations following a step-change in parameters applied at 30mins. (C) As in (B), for a step-change in parameters applied at 104mins. (D) $S_k^{V_{dau}}\left(t\right)$ and $S_k^{T_{S/G2/M}}\left(t\right)$ down generations as functions of time. Points from (B,C) are marked by blue and red circles, respectively. Vertical dashed lines represent the time of the G1-S transition.