Table 4. The composition (in % according to GC) of products mixture in the course of preparative oxidation of racemic decane-1,5-diol (1b) catalyzed by alcohol dehydrogenases.
| Enzyme | Time | Substrate | Products | ||||
|---|---|---|---|---|---|---|---|
| 1b | 2b and 3b | 4b | |||||
| [hours] | [%] | ee [%] | [%] | de [%] | [%] | ee [%] | |
| HLADH | 48 | 25 | - | 32 | - | 43 | 37 (+)-(R) |
| 120 | nd | 48 | 36 (2b) | 52 | 33 (+)-(R) | ||
| HLADH* | 48 | 89 | - | 11 | - | nd | |
| 120 | 41 | 5 | 28 | 58 (2b) | 31 | 56 (+)-(R) | |
*alcohol dehydrogenase recombinant from E. coli (HLADH); ee-enantiomeric excess
de-diastereoisomeric excess; nd-not detected