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. 2016 Jan 7;11(1):e0146529. doi: 10.1371/journal.pone.0146529

Fig 4. Effect of methamphetamine on metabolism of PIs in CYP3A4 human liver microsomes.

Fig 4

Effect of methamphetamine on (A) lopinavir M1 formation from lopinavir, (B) nelfinavir M8 degradation and, (C) hydroxy ritonavir formation from ritonavir. One way ANOVA with Dunnet’s post-hoc test was employed to calculate the statistical significance and ** denotes p-value <0.01.