Table 1. Summary of optimized parameters and characteristics for positive mode LC—MS/MS detection of Protease inhibitors.
MRM Parameters | |||||||
---|---|---|---|---|---|---|---|
Name | Q1 | Q3 | DP (V) | EP (V) | CE (V) | CXP (V) | tr (min) |
Lopinavir | 629.3 | 183.3 | 32 | 6 | 30 | 6 | 6.64 |
Lopinavir M1 | 643.3 | 250.3 | 32 | 6 | 37 | 6 | 6.36 |
Nelfinavir | 568.6 | 330.4 | 70 | 7 | 50 | 5 | 5.42 |
Nelfinavir M8 | 584.6 | 330.4 | 70 | 7 | 50 | 5 | 4.49 |
Ritonavir | 721.2 | 312.2 | 58 | 7 | 25 | 5 | 6.41 |
Hydroxy ritonavir | 737.2 | 340.5 | 58 | 7 | 25 | 5 | 5.26 |