Table 2. The KD and δAmax of all the PIs with and without methamphetamine.
No Methamphetamine | 100 μM Methamphetamine | ||||
---|---|---|---|---|---|
PIs | δAmax | KD (μM) | δAmax | KD (μM) | |
Lopinavir | 0.0070 ± 0.0002 | 2.5 ± 0.1 | 0.0078 ± 0.0005 | 4.1 ± 0.8 | |
Type I | Atazanavir | 0.0045 ± 0.0002 | 3.2 ± 0.8 | 0.0046 ± 0.0002 | 4.7 ± 0.7 |
Tipranavir | 0.0050 ± 0.0005 | 3.1 ± 0.1 | 0.0061 ± 0.0002 | 4.7 ± 0.4 | |
Nelfinavir | 0.0068 ± 0.0001 | 2.9 ± 0.1 | 0.0040 ± 0.0003* | 1.4 ± 0.3# | |
Type II | Ritonavir | 0.0055 ± 0.0003 | 0.065 ± 0.001 | 0.0038 ± 0.0003* | 0.043 ± 0.001* |
Indinavir | 0.0044 ± 0.0002 | 0.174 ± 0.030 | 0.0039 ± 0.0002 | 0.086 ± 0.010* |
*-indicates a p-value <0.05;
#-Indicates p-value <0.1