Table 3. The statistical results of PIs docking into CYP3A4 active site in the presence of methamphetamine.

	R-MA mode1	Average score [a]	Average score [b]	ΔScore	Average distance (Å) [c]	Average distance (Å) [d]	ΔDistance (Å)
	Lopinavir	51.6	47.84	3.76	3.16	5.45	-2.29
Type I	Atazanavir	44.62	41.88	2.74	3.61	6.42	-2.81
	Tipranavir	46.09	46.9	-0.81	3.75	6.33	-2.58
	Nelfinavir	49.16	47.57	1.59	3.6	5.31	-1.71
Type II	Ritonavir	57.56	46.75	10.81	3.16	5.7	-2.54
	Indinavir	55.88	52.37	3.51	3.37	5.74	-2.37

^a. Average score of major cluster in the absence of methamphetamine

^b. Average score of major cluster in the presence of methamphetamine

^c. The average distance between the atom of site closest to Fe and Fe for all top 10 conformers in the absence of methamphetamine.

^d. The average distance between the atom of site closest to Fe and Fe for all top 10 conformers in the presence of methamphetamine.