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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Jul 25;53(38):10067–10071. doi: 10.1002/anie.201403750

Table 1.

Signal transduction determined by the inositol phosphate accumulation assay, for all peptide–receptor combinations.

compound EC50/nM (pEC50 ± S.E.M.)
hY1R hY2R hY4R hY5R
pNPY 3.3
(8.5±0.1)		 0.3
(9.6±0.1)		 44.7
(7.4±0.3)		 4.7
(8.3±0.1)
1A 76.0
(7.1±0.1)		 341.4
(6.5±0.1)		 1.3
(8.9±0.1)		 11.4
(7.9±0.1)
2A 51.6
(7.3±0.1)		 0.4
(9.4±0.2)		 1.0
(9.0±0.2)		 6.5
(8.2±0.2)
3A 83.5
(7.1±0.0)		 2.8
(8.6±0.2)		 2.1
(8.7±0.1)		 6.7
(8.2±0.3)
4A > 1000
(5.2±0.1)		 11.7
(7.9±0.1)		 2.9
(8.5±0.1)		 195.3
(6.7±0.2)
5A > 1000
(4.7±0.1)		 32.4
(7.5±0.1)		 13.8
(7.9±0.1)		 > 1000
(5.9±0.1)