Table 1.

Characteristics of patients with initially proven and suspected invasive candidiasis

Patients’ characteristics	SAT for initially proven invasive candidiasis N = 291	SAT for suspected invasive candidiasis N = 544	P value
At ICU admission
Age (years)	62.2 ± 15.4	61.9 ± 14.5	0.93
Male gender	185 (63.6)	337 (62.0)	0.64
Reason for admission to ICU
Medical	119 (40.9)	268 (49.3)	0.02
Surgical	161 (55.3)	260 (47.8)	0.04
Trauma	16 (5.5)	16 (2.9)	0.08
C-reactive protein (mg/L)	165.9 ± 109.4	173.1 ± 122.6	0.67
Creatinine (µmol/L)	145.8 ± 109.6	132.1 ± 96.9	0.13
Red blood cell transfusion in ICU	163 (56.0)	289 (53.1)	0.42
Platelet transfusion in ICU	60 (20.6)	119 (21.9)	0.67
At SAT initiation
Length of hospital stay before SAT (days)	13 [6; 23]	11 [4; 20]	<0.01
Length of ICU stay before SAT (days)	5 [2; 14]	4 [0; 11]	<0.01
Body temperature (°C)	37.6 ± 1.3	37.7 ± 1.3	0.34
SAPS II	46.2 ± 18.0	50.1 ± 18.7	0.006
SOFA score	7.3 ± 4.8	8.3 ± 4.3	0.0007
Septic shock	120 (41.2)	330 (66.7)	<0.0001
Severe sepsis	118 (40.6)	203 (37.3)	0.36
Risk factors for invasive candidiasisa
Invasive mechanical ventilation	196 (67.4)	458 (84.2)	<0.0001
Central venous catheter	278 (95.5)	526 (96.7)	0.44
Urinary catheterization	280 (96.2)	516 (94.9)	0.50
Antibiotic treatment	268 (92.1)	481 (88.4)	0.12
Total parenteral nutrition	149 (51.2)	235 (43.2)	0.03
Hemodialysis or hemodiafiltration	92 (31.6)	160 (29.4)	0.51
Corticosteroid treatment	55 (18.9)	151 (27.8)	0.005
Surgery just before or during ICU stay	197 (67.7)	341 (62.7)	0.15
Abdominal surgery	156 (78.2)	263 (79.2)	0.80
Scheduled abdominal surgery	16 (10.3)	48 (18.3)	0.03
Emergency abdominal surgery	140 (89.7)	215 (81.7)	0.03
Mortality on D28	96 (34.4 %)	163 (31.6 %)	0.42

The results are given as n (%) or mean ± SD, when indicated

SAT systemic antifungal therapy, ICU intensive care unit, SOFA sequential organ failure assessment; SAPS II: simplified acute physiology score

^aRisk factors as per IDSA and ESCMID guidelines (3, 4)