Table 2. Correlation between cancer stem cell marker expressions and clinicopathological parameters.
| Parameter | CD133 | ALDH1 | ||||
|---|---|---|---|---|---|---|
| Negative, No. (%) | Positive, No. (%) | p-value | Negative, No. (%) | Positive, No. (%) | p-value | |
| Age (yr) | 0.373 | 0.759 | ||||
| ≤ 35 | 14 (87.5) | 2 (12.5) | 12 (75.0) | 4 (25.0) | ||
| > 35 | 205 (74.5) | 70 (25.5) | 215 (78.2) | 60 (21.8) | ||
| Tumor size (cm) | 0.001 | 0.004 | ||||
| ≤ 2.0 | 112 (84.8) | 20 (15.2) | 113 (85.6) | 19 (14.4) | ||
| > 2.0 | 107 (67.3) | 52 (32.7) | 114 (71.7) | 45 (28.3) | ||
| LN metastasis | 0.019 | 0.223 | ||||
| Negative | 149 (79.7) | 38 (20.3) | 150 (80.2) | 37 (19.8) | ||
| Positive | 70 (67.3) | 34 (32.7) | 77 (74.0) | 27 (26.0) | ||
| Stage | 0.001 | 0.011 | ||||
| I | 92 (85.2) | 16 (14.8) | 92 (85.2) | 16 (14.8) | ||
| II | 98 (73.7) | 35 (26.3) | 103 (77.4) | 30 (22.6) | ||
| III | 29 (58.0) | 21 (42.0) | 32 (64.0) | 18 (36.0) | ||
| Histological grade | 0.111 | 0.055 | ||||
| 1 and 2 | 118 (79.2) | 31 (20.8) | 123 (82.5) | 26 (17.5) | ||
| 3 | 101 (71.1) | 41 (28.9) | 104 (73.2) | 38 (26.8) | ||
| ER | 0.001 | 0.001 | ||||
| Negative | 54 (51.9) | 50 (48.1) | 66 (63.5) | 38 (36.5) | ||
| Positive | 164 (88.2) | 22 (11.8) | 160 (86.0) | 26 (14.0) | ||
| PR | 0.024 | 0.655 | ||||
| Negative | 109 (69.9) | 47 (30.1) | 120 (76.9) | 36 (23.1) | ||
| Positive | 109 (81.3) | 25 (18.7) | 106 (79.1) | 28 (20.9) | ||
| HER2 | 0.001 | 0.050 | ||||
| Negative | 190 (78.8) | 51 (21.2) | 193 (80.1) | 48 (19.9) | ||
| Positive | 28 (57.1) | 21 (42.9) | 33 (67.4) | 16 (32.6) | ||
| Luminal | < 0.001 | 0.001 | ||||
| No | 43 (53.8) | 37 (46.2) | 52 (65.0) | 28 (35.0) | ||
| Yes | 175 (83.3) | 35 (16.7) | 174 (82.9) | 36 (17.1) | ||
| TNBC | < 0.001 | 0.023 | ||||
| No | 183 (79.9) | 46 (20.1) | 185 (80.8) | 44 (19.2) | ||
| Yes | 35 (57.4) | 26 (42.6) | 41 (67.2) | 20 (32.8) | ||
| RTx | 0.457 | 0.616 | ||||
| No | 70 (72.2) | 27 (27.8) | 78 (80.4) | 19 (19.6) | ||
| Yes | 141 (76.2) | 44 (23.8) | 144 (77.8) | 41 (22.2) | ||
| CTx | 0.041 | 0.471 | ||||
| No | 12 (100.0) | 0 | 11 (91.7) | 1 (8.3) | ||
| Yes | 200 (73.5) | 72 (26.5) | 213 (78.3) | 59 (21.7) | ||
| Recurrence | 0.001 | 0.046 | ||||
| No | 201 (78.2) | 56 (21.8) | 205 (79.8) | 52 (20.2) | ||
| Yes | 18 (52.9) | 16 (47.1) | 22 (64.7) | 12 (35.3) | ||
ALDH1=aldehyde dehydrogenase 1; LN=lymph node; ER=estrogen receptor; PR=progesterone receptor; HER2=human epidermal growth factor receptor 2; TNBC=triple-negative breast cancer; RTx=radiotherapy; CTx=chemotherapy.