Table 4. Multivariate analysis for overall survival after metastasis using the Cox regression hazard method.
| Factor | With continuous MFI | With categorical MFI | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | |
| MFI | ||||
| Continuous | 0.964 (0.957-0.970) | < 0.001 | NA | |
| MFI | NA | |||
| Short | Reference | |||
| Intermediate | 0.239 (0.174-0.330) | < 0.001 | ||
| Long | 0.063 (0.039-0.102) | < 0.001 | ||
| Hormone receptor status | 0.003 | 0.001 | ||
| Negative | Reference | Reference | ||
| Positive | 0.650 (0.490-0.863) | 0.627 (0.471-0.836) | ||
| Nodal status | 0.009 | 0.053 | ||
| Positive | Reference | Reference | ||
| Negative | 0.584 (0.391-0.873) | 0.676 (0.455-1.005) | ||
| Stage | ||||
| III | Reference | Reference | ||
| II | 0.884 (0.494-1.581) | 0.678 | 1.032 (0.579-1.837) | 0.139 |
| 0 & I | 0.666 (0.389-1.140) | 0.139 | 0.726 (0.424-1.242) | 0.678 |
| Metastatic site | ||||
| Multiple | Reference | Reference | ||
| Viscera | 1.071 (0.795-1.444) | 0.653 | 1.054 (0.699-1.286) | 0.734 |
| Bone | 0.466 (0.320-0.678) | < 0.001 | 0.439 (0.300-0.641) | < 0.001 |
MFI=metastasis-free interval; CI=confidence interval; NA=not applicable.