Table 1. Number of secondary malignancies observed between 1996 and 2007 after primary breast cancer and cumulative incidence by Gooley method.
| Cancer type | No. | Cumulative incidence at 8 yr (%) | 95% CI |
|---|---|---|---|
| Contralateral breast cancer | 69 | 1.64 | 1.24-2.12 |
| Digestive system* | 55 | 1.17 | 0.86-1.55 |
| Nonmelanoma skin | 46 | 1.16 | 0.84-1.57 |
| Genital system† | 42 | 0.98 | 0.69-1.37 |
| Urinary system‡ | 16 | 0.43 | 0.25-0.71 |
| Lung | 15 | 0.31 | 0.17-0.52 |
| Thyroid | 11 | 0.28 | 0.15-0.50 |
| Melanoma | 7 | 0.21 | 0.09-0.43 |
| Head and neck | 6 | 0.19 | 0.08-0.43 |
| Other§ | 9 | 1.77 | 1.36-2.28 |
| Solid cancer (excluding contralateral breast cancer) | 207 | 4.96 | 4.27-5.28 |
| Hematological malignanciesII | 29 | 0.65 | 0.43-0.96 |
| Total | 305 | 7.27 | 6.42-8.18 |
Data from 4,776 cases selected from 6,325 women recorded by Modena Cancer Registry between 1996 and 2007.
CI=confidence interval.
*Digestive system: esophagus, stomach, small intestine, colon, rectum, liver and pancreas; †Genital system: cervix and corpus uteri, ovary, other female genital organs; ‡Urinary system: kidney and bladder; §Other: mesothelioma; soft tissue neoplasia, including heart, other endocrine, and thymus; and miscellaneous or unspecified neoplasia; ∥Hematological malignancies: Hodgkin and non-Hodgkin lymphoma, acute and chronic lymphocytic leukemia, acute and chronic myeloid leukemia, acute monocytic leukemia, myeloma, myeloproliferative and myelodysplastic syndrome.