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. 2015 Dec 18;155:53–63. doi: 10.1007/s10549-015-3657-z

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — AuroraB depletion partially recapitulates the effects of Survivin depletion on HR genes' expression a Cell cycle progression was assessed by PI staining and flow cytometry analysis, in Cal51 and MDAMB-231 cells upon Survivin (SiSurvivin), AuroraB (SiAuroraB) depletion. Data are presented as % of cells in cell cycle phases, obtained at 1, 2, and 3 days after RNA interference. b CyclinB1 expression was studied by immunoblot in Survivin (SiSurvivin), AuroraB (SiAuroraB), or CDC20 (SiCDC20) depleted cells. c Expression of HR genes, BIRC5, AURKB, and CDC20 was assessed by qPCR after Survivin (SiSurvivin), AuroraB (SiAuroraB), or CDC20 (SiCDC20) depletion. Data are presented as means of ratios obtained using data from control condition (SiCt) in a heatmap. The green scale indicates decreased mRNA, and the red scale increased mRNA. Statistical significativity was indicated as following ***p < 0.001, **p < 0.05, *p < 0.01. (ns not significative)